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The Antioxidant Capacity of Lactate Dehydrogenase

Haley McDonough
Haley McDonough
Faculty Adviser(s)

Reactive oxygen species (ROS) are highly reactive molecules that occur as a result of naturally occurring reduction-oxidation (REDOX) reactions in the body. The amount of ROS present in the body is influenced by both endogenous factors, such as mitochondrial reactions, and exogenous factors, such as cigarette smoking. When the amount of ROS increases to a point beyond what is considered normal, the body enters a state of oxidative stress. Oxidative stress is linked to many disorders including neurological disorders, autism, cancer, and more. The regulation of the amount of ROS in the body is important to preserve the proper function of cellular activity. The body primarily regulates the amount of ROS in the body through the use of antioxidants. Antioxidants are molecules that reduce ROS and render them inactive, leaving them incapable of disrupting cellular function. Antioxidant proteins have been a major source of scientific research because proteins play a diverse role in protecting the body against the effects of ROS. In this study, the antioxidant activity of bovine serum albumin (BSA) and lactate dehydrogenase (LDH) was examined. The purpose of this study was to visualize and predict the site of interactions capable of producing antioxidant activity through the use of computational protein-docking programs.    


Haley McDonough is a senior at Salem College graduating with a dual degree in Religious Studies and Biochemistry. She aspires to pursue a career in Dentistry. She lives in Kernersville, North Carolina and enjoys spending time with her family, friends, and pets in her free time.